Denosumab also decreases bone resorption by inhibiting maturation of osteoclasts through binding to a receptor on the surface of 'pre-osteoclast cells,'. Robert McLean More Quotes by Robert McLean More Quotes From Robert McLean There is now a specific recommendation against using estrogen replacement therapy or raloxifene (Evista) for treatment of osteoporosis in women. Robert McLean top-news There is now a more specific recommendation for shared decision-making with patients in the specific situation of osteopenic women over the age of 65. Robert McLean top-news