More or less, what causes desperation, depression or hopelessness is nothing else but lack of motivation and inspiration i.e. anyone who is not often inspired or motivated is likely to become despaired, desperate or hopeless in life. But on the other hand, anyone who is often inspired and motivated will hardly feel depressed, despaired or hopeless in life. Therefore, do source, search and always go for inspirations and motivations as often as you can. -Emeasoba George