Our experience with variants such as the Delta variant is that even though the vaccine isn't specifically targeted to the Delta variant, when you get a high enough level of an immune response, you get spillover protection, even against a variant that the vaccine wasn't specifically directed at, that's the reason why we feel even though we don't have a lot of data on it, there's every reason to believe that that kind of increase that you get with the boost would be helpful, at least in preventing severe disease of a variant like Omicron.

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