Rudy Tanzi

We know that amyloid deposition starts a decade or so before symptoms and it's too late to treat it then, it's like trying to put out a forest fire by putting out the match.

It has to be early detection and early treatment, years before symptoms begin, for it to work, when is big pharma going to learn ?

Already, Alzheimer's consumes one in every five Medicare/Medicaid dollars, with 71 million baby boomers headed toward risk age, this will go to one in three, perhaps in the next decade, at which point Alzheimer's will single-handedly collapse Medicare/Medicaid.

There was an apparently beneficial effect on immediate word recall in those with mild cognitive impairment, this preliminary but promising finding warrants more exploration of the use of bioelectronic approaches for disorders like Alzheimer's disease.

It is important to emphasize that the study mainly shows modest but significant improvement in short-term memory, but does not show clear effects on long-term memory since the test was based on word recall only a minute or so after learning the words, cognitive experts would say what you recall from an hour ago is long-term memory.

We were able to rapidly screen every approved drug and over 1,000 natural products, and now we have over 150 identified drugs and natural products that could be tested in clinical trials to hit plaques, tangles or neuroinflammation.

It's all about hitting the right person with the right drug, at the right time in the course of their disease, many people may not know this, but after 40 years old, just about all of us start to build up the initiating pathology of Alzheimer's, which is amyloid plaque in the brain and the neurofibrillary tangles.

I like to say the amyloid is like the match, and the tangles are like brush fires that propagate and spread over decades, and along the way you're triggering big forest fires, that's neuroinflammation.

The elephant in the room is that we wait until the brain deteriorates to the point of dysfunction before we treat this disease, that's like saying wait until you lose half of the beta cells in your pancreas before we diagnose diabetes.

I want to make it clear to people that to end Alzheimer's, we need early detection, early intervention some 10, 20 years before symptoms show up, and what about the 6 million people in this country with this disease right now? For them, we need to put out the fire, stop the neuroinflammation, stop the killing of neurons.

The most interesting aspect of the study is that APOE4 differentiated women from men, it's possible that APOE4 either increases amyloid burden in women more than men. Or, perhaps, once amyloid accumulates, it leads to a fast cascade of pathology and neurodegenration in women versus men.

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